biosensors, to date, have been not only employed in the early stages of drug discovery by screening potential targets and combinatorial libraries, but also moving down the pipeline and being used for significant quantitative measurements 摘要现今的研究潮流,药物开发是一股势不可挡的趋势,除了要能有效快速的进行活性筛选工作之外,也必须对筛选出之先导物有能力进行更进一步的深入分析,而生物感测正可以符合这些药物开发的需求。
examples of microfluidics-based applications include screening of biological targets, synthesis of combinatorial libraries, synthesis of dna oligomers, and analysis of polymorphic proteins, all of which can be performed in large high-throughput parallel arrays because of microfluidics 显微射流技术应用的例子包括生物靶子的筛选、组合文库的形成、dna寡聚体的合成,蛋白质多态性研究所有这些都因为显微射流技术而可以大规模进行。
conentional methods such as fractionation of complex clinical samples by ionic exchange chromatography and new methods such as enriching low abundant proteins by affinity capture with a combinatorial library of ligands14 proide much needed tools for processing complex biological and clinical samples for proteomics research 传统(如对复杂临床样品通过离子交换层析进行分离)和现代的方法(如通过亲和捕获与配体库的组合富集低丰度蛋白)为处理用于蛋白质组学研究的复杂的生物学与临床样品提供了极需的工具。