in the early neurula, cortactin staining signals were detected in the developing primodium of forebrain as early as 10.5 hpf ( hours post fertilization ), at the same time the tailbud areas were highly stained too . later, the staining was concentrating in the developing neural rod while paraxial mesoderm derivatives were not stained 在早期神经胚,神经系统中的前脑原基最先出现染色,并保持头尾两端处染色最强的图式,随后,染色集中分布在发育中的神经龙骨中,但近轴中胚层细胞没有染色。