The avermetins are a group of closely related macrocylic lactones with exceedingly high activity against helminths and anthropods . this paper review the biosyntheticpathway of the avermectins and the organization of the biosynthetic gene cluster which many groups have analysed and cloned 阿维菌素为一种典型的次级代谢产物,生物合成途径复杂,现在基本上对每一步合成途径的基因及其所编码的酶都有所了解。