hyperphosphorylation造句

例句与造句

1. Mutations that alter function and isoform expression of tau lead to hyperphosphorylation.
2. This aggregated tau is often severely modified, most commonly through hyperphosphorylation.
3. Scientists have used a variety of tools to unravel the role of hyperphosphorylation.
4. After mice are given cocaine, a strong and momentary hyperphosphorylation of Erk and Elk1 is observed in the striatum.
5. CPI-17 is up-regulated some cancer cells, and causes hyperphosphorylation of tumor suppressor merlin / NF2.
6. It's difficult to find hyperphosphorylation in a sentence. 用hyperphosphorylation造句挺难的
7. In addition, hypophosphorylation and hyperphosphorylation of ASF / SF2 by Clk / Sty can lead to inhibition of splicing.
8. Thus, the hyperphosphorylation of tau leads to massive detachment, which in turn greatly reduces the stability of microtubules in nerve cells.
9. However, consensus has not been reached on whether tau hyperphosphorylation precedes or is caused by the formation of the abnormal helical filament aggregates.
10. Hyperphosphorylation of a number of proteins-the paratarg proteins-a tendency which is inherited in an autosomal dominant manner appears a common mechanism in these families.
11. Sodium selenate increases PP2A activity which decreases tau hyperphosphorylation, indicating that CAPPs may be manipulated to affect brain function ( Tan et al ., 2016 ).
12. GSK-3 is thought to directly promote A? production and to be tied to the process of the hyperphosphorylation of tau proteins, which leads to the tangles.
13. An increased amount of phosphorylation ( hyperphosphorylation ) leads to increased deacetylase activity, but degrades complex formation between HDACs 1 and 2 and between HDAC1 and mSin3A / YY1.
14. It is hypothesized that anterograde transneuronal degeneration causes the hyperphosphorylation of the tau protein and redistributing those proteins from the axon to the dendrites, which begins the breakdown of routing and sorting mechanisms.
15. There is an adequate amount that the tau protein needs to be phosphorylated to function, but hyperphosphorylation of tau protein is thought to be one of the major influences on its incapacity to associate.
16. Alzheimer Disease tau seems to remove MAP1 and MAP2 ( two other major associated proteins ) from microtubules and this deleterious effect is reversed when dephosphorylation is performed, evidencing hyperphosphorylation as the sole cause of the crippling activity.
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